Hundreds of people were arrested as protesters and police clashed in cities across America after the killing of George Floyd, an unarmed black man, at the hands of Minneapolis police sparked more than 100 protests, rallies and vigils over the weekend, according to NBC News. 

Mayors of major cities from Los Angeles to Philadelphia to Atlanta imposed curfews and at least 12 states, as well as Washington, D.C., activated National Guard troops in an effort to keep the peace overnight, but protests in several cities descended into violence again as tensions boiled over. 

Derek Chauvin, the officer filmed kneeling on Floyd’s neck, was arrested and charged with murder and manslaughter.

This is CNBC’s live blog covering all the latest news on the demonstrations gripping the U.S. This blog will be updated throughout the day as the news breaks. 

3:47 p.m. ET â€” Nearly 400 people were arrested on Saturday during protests in Los Angeles, according to the LAPD.

The charges include burglary and looting, vandalism, arson and curfew violations. The authorities said that five officers were injured and two were hospitalized.

Los Angeles Mayor Eric Garcetti said that some coronavirus test sites may not open on Monday due to the unrest, though the largest testing center at Dodger Stadium will remain open.

The city is under curfew starting Sunday at 8 pm PST, after which protesters could be arrested for breaking curfew. 

3:37 p.m. ET â€” Apple announced that it would not open many of its stores on Sunday due to the protests against police violence.

“With the health and safety of our teams in mind, we’ve made the decision to keep a number of our stores in the US closed on Sunday,” the company said in a statement.

Apple has 271 stores in the United States, and about half of those are already closed because of the pandemic. The tech company reopened roughly 100 stores last week.

2:41 p.m. ET â€” Police arrested 10 people in San Francisco on Saturday night for looting as demonstrators protested throughout the city, according to San Francisco Chief of Police Bill Scott. 

Scott said several businesses were damaged and fires were “intentionally set” across the city. “It was a challenging night,” Scott said. “We didn’t have anyone killed, fortunately.”

San Francisco Mayor London Breed announced late Saturday that the city will go under a curfew starting Sunday night as a result of the protests. The curfew will last from 8 p.m. to 5 a.m.

2 p.m. ET â€” Eleven Secret Service employees went to the hospital for non-life threatening injuries sustained during protests in Washington, DC, on Saturday, the agency said.

The Secret Service said in a tweet that its officers made one arrest during the demonstration and that no protesters crossed the White House fence.

Peter Newsham, chief of DC’s Metropolitan Police Department, said at a news conference on Sunday that the MPD had made 17 arrests, the majority of whom were from D.C. or surrounding cities.

Newsham said he expects the department to make more arrests as police view video footage from security cameras at businesses.

Newsham said that during the protest three vehicles were set on fire near Lafayette Park, which is directly north of the White House. Eleven MPD officers were injured during the protests, including one who required surgery for a broken leg. The chief said that officers used pepper spray against some demonstrators.

1:19 p.m. ET â€” Police arrested 240 people in Chicago on Saturday night in connection with protests and lootings, according to Chicago Police Superintendent David Brown.

Authorities said that there were 6 shootings and one death. More than 20 police officers were injured during altercations with demonstrators.

Governor JB Pritzker on Sunday activated 375 Illinois National Guard members to aid the police. No public transportation including trains and buses is allowed to and from the nation’s third largest city, which is under a 9 p.m. curfew as more protests are anticipated on Sunday.

All police days off have been cancelled and officers are on 12-hour shifts. 

1 p.m. ET â€” President Donald Trump said on Twitter on Sunday that the United States would designate Antifa as a terrorist organization, blaming “Antifa-led anarchists” for the violence and destruction in Minneapolis without presenting any evidence to the public. 

This is not the first time Trump has mentioned declaring Antifa, a loosely organized movement of left-wing activists whose name is short for “anti-fascist,” a terrorist group. The president said in a tweet last August that “major consideration is being given” to declaring Antifa as a terrorist organization.

Trump’s statement comes as political officials in several cities have blamed outside groups for escalating protests. Minneapolis Mayor Jacob Frey tweeted on Saturday that, “We are now confronting white supremacists, members of organized crime, out of state instigators, and possibly even foreign actors to destroy and destabilize our city and our region.”

Minnesota officials, including Frey, also said that the majority of protestors were from out of state. An analysis by NBC affiliate KARE 11, however, showed that arrest records did not support that assertion.

11:50 a.m. ET â€” The New York Police Department said they arrested nearly 350 people on Saturday night following protests in Harlem, Brooklyn and Staten Island. NYPD Commissioner Dermot Shea said in a press conference on Sunday that more than 30 officers suffered minor injuries as a result of clashes with demonstrators.

Shea said a group of protesters in Harlem turned a peaceful demonstration violent, calling it a “hijacking” of a protest that otherwise went “overwhelmingly well.” The protesters caused damage to private and public property in Brooklyn and parts of southern Manhattan near Union Square, Shea said.

On Saturday, New York City Mayor Bill de Blasio said he’d launch an independent review of Friday night’s protests in Brooklyn. De Blasio acknowledged Sunday that there were “mistakes,” as well as “things that were done right” by the police during the demonstrations.

“There will be critiques, and there will be things that need to be investigated, and there will need to be things improved, and we expect to do better today than we did yesterday, but I want to commend the restraint that we saw overall from the NYPD,” he said.

11:38 a.m. ET â€” Police made at least 55 arrests in Minneapolis and St. Paul overnight, a large number of which were for weapons violations including rifles, according to the Minnesota Department of Public Safety.

“I want people to think about this, a large number of the arrests we made over last night were for weapons violations,” Commissioner John Harrington said. “We took AR-15s off of people, we took guns off people.”

Police moved to stop cars driving through neighborhoods without license plates, with lights out and windows blacked out, Harrington said. Several were stolen and were full of rocks and other weapons, he said. 

One police officer was fired upon from a car but was not hit, according to Harrington. Two people were arrested and an AR-15 rifle was seized, he said. 

The arrest data is preliminary and another 40 or 50 people were likely arrested overnight, Harrington added. Authorities said there were no major fires overnight. 

10:55 a.m. ET â€” Rep. Ilhan Omar, D-Minn., said on ABC’s “This Week” that the U.S. needs “nationwide reforms,” not just the arrest of a police officer, in order to deliver justice for George Floyd.

“The unrest we are seeing in our nation isn’t just because of the life that was taken, it’s also because so many people have experienced this,” Omar told ABC’s George Stephanopoulos. “So many people have experienced injustices within our system.”

On Friday, Derek Chauvin, a former Minneapolis police officer who was filmed kneeling on Floyd’s neck before he died, was taken into custody. Chauvin was charged with third-degree murder and second-degree manslaughter. Chauvin was among the four officers involved in Floyd’s violent arrest.

Since then, protesters have called for the arrest of the other officers “who stood by idly watching [Floyd’s] life be taken,” Omar said. 

“We need nationwide reforms,” Omar said. “We need to really step back and say to ourselves, ‘Where do we actually go from here?’ and that can’t just be getting justice for George Floyd. It needs to be bigger than that,” she added.

10:49 a.m. ET â€” House Speaker Nancy Pelosi backed the nationwide protests against racism and police brutality spurred by the killing of George Floyd, and criticized President Donald Trump’s handling of the situation.

“There’s a place for protest at a sign of a knee going into the neck of a person who’s not offering resistance or even if he were, disproportionate response from the police,” Pelosi said on ABC’s “This Week.”

Pelosi said the president should bring dignity to the office, and “unify our country and not to fuel the flame.”

“To take his bait time and time again is just a gift to him because he always wants to divert attention from what the cause of the response was rather than to describe it in his own terms,” Pelosi said.

10:10 a.m. ET â€” Melvin Carter, mayor of St. Paul, Minnesota, said on CNN’s “State of the Union” that proof of progress on police reform would be more helpful to quell the protests in his city than additional help from the National Guard.

“The thing that I think would help us more than military support is some assurance across our country that we possess a legal and judicial system that has the capacity and the capability to hold someone accountable when something this blatant, something this disgusting, something this well-documented happens in plain view for all of us to see,” Carter said.

Carter said laws and police union contracts are among the things that need to change to hold police accountable. The mayor also said that he wanted to see the other officers involved in George Floyd’s death to be held accountable, but he did not say if he thought they should be charged with murder. 

Over 170 businesses have been damaged in the city during the demonstrations so far. Carter said that while many protestors were there to push for change after Floyd’s death, others were there to be destructive.

“There are folks in our streets who are there to burn down our black-owned barbershops, to burn down our family-owned businesses, our immigrant-owned restaurants,” Carter said. “And it is very clear to me that those people are not driven by a love for our community, and there’s no way you can argue that those actions are designed to create a better future for our community, quite the opposite.”

10:05 a.m. ET â€”  Atlanta Mayor Keisha Bottoms condemned President Donald Trump’s calls for the federal government to step up military action against protesters. 

“This is like Charlottesville all over again,” Bottoms told CNN’s Jake Tapper on “State of the Union.” “He speaks and he makes it worse.”

Crowds gathered outside the White House Friday and Saturday night in protest of George Floyd’s death. Trump tweeted Saturday that had the protesters breached barriers set up by the U.S. Secret Service, they would “have been greeted with the most vicious dogs, and most ominous weapons.”

Later on Saturday, Trump called for states to “get MUCH tougher” or the federal government would step in and “do what has to be done,” including “using the unlimited power of our military.”

9:59 a.m. ET â€” White House National Security Advisor Robert O’Brien told reporters that the U.S. will not federalize the National Guard amid nationwide protests over the killing of George Floyd.

“We’re not going to federalize the Guard at this time,” O’Brien said. “If the governors need it, we’re there as a reserve and we’ll do whatever they need to keep control of their cities.

“We want governors to take control of their cities,” O’Brien continued. “We’d like to keep this a law enforcement matter, that’s our preference,” he added. “But if a situation gets out of control there are military that can be deployed. But we hope that doesn’t happen.”

On Saturday night, Minnesota National Guard members were firing tear gas and rubber bullets at demonstrators who were out past curfew. Governors have mobilized National Guard in California, Georgia, Kentucky, Washington and Tennessee among others in response to rioting. 

5:25 a.m. ET â€” In Nashville, 28 protesters were arrested Saturday night after the 10 p.m. curfew, according to the Nashville Police Department.

Governor Bill Lee authorized the National Guard to mobilize in response to protests, which he said took a “violent, unlawful turn.”

Protesters damaged at least 30 businesses and buildings in the city, including the Nashville courthouse, which was set on fire. No officers were injured, according to the police department.

4:36 a.m. ET â€” Target has temporarily closed 175 stores across the country amid ongoing protests, the company announced late Saturday.

“Our focus will remain on our team members’ safety and helping our community heal,” the company said.

Target closed 71 stores in Minnesota, which has been gripped by demonstrations and rioting following the death of George Floyd, an unarmed black man, after a white officer pressed a knee into his neck while taking him into custody.

At least a dozen stores are closed in California and New York. Any Target employees impacted by store closures will be paid for up to 14 days of scheduled hours, including Covid-19 premium pay, the company said.

Employees can also work at other nearby Target locations that remain open. Some businesses have been looted and vandalized in cities across the U.S. as protests turned violent, including a Target store in Minneapolis.

4:15 am ET â€” More than 20 people were arrested in Seattle during Saturday’s protest, Seattle Police Chief Carmen Best said in a statement early Sunday morning. Best said that “multiple officers and civilians have been injured” but did not give further details about those injuries.

The protests in Seattle were peaceful for more than two hours before escalating, and some of the demonstrators set fire to police and private vehicles, according to the statement. Mayor Jenny Durkan ordered a curfew from 5 p.m. to 5 a.m. local time. At the time of the statement, the Seattle police and the National Guard were still working to remove people from the city’s downtown core.

2:35 a.m. ET â€” The Philadelphia Police Department said on Twitter that 13 of its officers were injured, including seven with chemical burns to their faces, as officers made more than 100 arrests during Saturday’s protests.

Philadelphia Mayor Jim Kenney imposed a curfew last night from 8 p.m. to 6 a.m. local time. That curfew is set to repeat on Sunday night. Curfew violations accounted for 52 of the arrests, while another 43 were for looting or burglary, according to the department. There was one arrest for assaulting an officer.

2:16 a.m. ET â€” California Governor Gavin Newsom declared a state of emergency in Los Angeles and approved the city’s request to deploy the National Guard to help deal with escalating protests.

Coronavirus testing centers in Los Angeles are also temporarily closed as a result of the unrest. Mark Ridley-Thomas, Los Angeles County supervisor, said the closing of the testing sites was a “troubling consequence of social breakdown prompted by excessive use of force resulting in the death of another unarmed African American man.”